Evaluation of biochemical and inflammatory profiles of obese patients undergoing bariatric surgery

Obesity has become an increasing source of morbidity and mortality in Turkey and all over the world. For this reason, efforts have been made to draw attention to the fight against obesity in recent years. Obesity treatment is long-term and requires a multidisciplinary treatment protocol. Adipokines are bioactive proteins synthesized from adipose tissue and have proinflammatory and anti-inflammatory effects. In obesity, high levels of adipokines released from adipose tissue have been reported to cause oxidative stress and inflammation. In obesity, the increase in fat mass is associated with the interaction of T lymphocytes and macrophages in adipose tissue. This relationship leads to increased activity of proinflammatory cytokines in adipose tissue. Recent studies show that proinflammatory cytokines such as IL-6, TNF-α, CRP and acute phase proteins are high in obese individuals. Asprosin is an adipokine released from adipose tissue and has important effects on metabolism. Although the causal relationship between asprosin and obesity is not fully understood, there is increasing evidence that asprosin is a new molecule that plays a very important role in metabolic pathways and can be used as a biomarker and target molecule for obesity. In the light of all this information, this thesis study was planned to investigate the effects of bariatric surgery on serum Asprosin, C-Reactive Protein (CRP) and IL-6 (interleukin-6) values. The study included 44 patients who applied to the General Surgery Clinic of Malatya Turgut Ozal University Training and Research Hospital, who decided to undergo obesity surgery and agreed to participate in the study. Serum samples of individuals who underwent bariatric surgery were taken pre-operatively and at 1., 3. and 6. months post-operatively and asprosin, CRP and IL-6 levels were measured. The effect of surgical intervention on these biomarkers was evaluated by comparing the values before and after bariatric surgery. As a result of our study, in line with the results of other studies, we found that while the preoperative values of asprosin, CRP and IL-6 levels were high in individuals who had undergone obesity surgery, these values decreased with postoperative weight loss. We believe that evaluating asprosin, CRP, and IL-6 levels together with weight loss after obesity surgery will contribute to the literature in light of these results. KEYWORDS: Obesity, Bariatric Surgery, Asprosin, C-Reactive Protein, Interleukin-6