The synthesis of novel chalcone derivatives and investigation of biological activities

Chalcones represent essential groups of natural products. In addition, many researchs that have been done recently indicate that chalcones shows many usefull possess including antifungal, antimicrobial, antitubeculosis, anticancer and antioxidant. As chalcone has such a wide range of pharmacological activities, it directed to us synthesis of chalcone with different substituted and investigate their pharmacologically activities. In this study, 10 different substituted chalcone derivatives were syntesized and their pharmacological activites were investigated. All of reactions was monitored by Thin Layer Chromatography (TLC) and crude product purified by crystalization from appropriate solvents. The structures of synthesized compounds were elucidated by spectroscopy method as UV, IR, ¹H NMR and elemental analysis (C, H, N) as well as of physical and chemical methods. In addition pharmacological activites of synthesized chalcones were investigated