Bazı sülfonamit bileşiklerinin ve metal komplekslerinin sentezi, karbonik anhidraz inhibisyon özelliklerinin tespiti, biyolojik aktivitelerinin incelenmesi

In the first phase of this research, a series of Schiff bases were synthesized by the reaction of various aldehydes of sulfamethoxazole and sulfisoxazole ligands of the sulfonamide species and elemental analysis of their structures, characterized by 1H-NMR, 13C-NMR, FT-IR, LC-MS and UV-vis methods. In addition, Cu (II) and Pd (II) complexes of synthesized Schiff bases were synthesized and their structures were determined by spectroscopic methods, thermal studies, magnetic and conductivity measurements. In the second step, the inhibition of synthesized Schiff bases and complexes against CA I and CA II isoenzymes was investigated. In the third stage, the conformation analysis of the compounds synthesized by DFT / B3LYP method in GAUSSIAN 09 package program yielded the lowest energy molecular structures. hus, the relationship between the molecular properties of the compounds and their biological activities was determined.