Investigation of Growth Inhibiting Factor-2 functions in basal cell carcinoma

Based on double hit hypothesis used for describing tumor supressor genes, LOH (loss of heterozygosity) analysis on basal cell carcinomas (BCC) pointed out an increase in chromosome 4q22-35 deletion, which shows that one of the genes at this locus is a candidate tumor supressor gene.ING-2 is a member of ING gene family and functions in DNA repair, cell division and apoptosis. In order to determine the function of this gene in basal cell carcinoma, the m-RNA expressions among normal and tumoral tissues were compared.As a result, the decreased expression of m-RNA of ING-2 gene in tumoral tissues compared to that of normal tissues suggests that ING-2 gene is a tumor supressor gene for BCC.