Investigation of analgesic and anti-inflammatory effects of controlled release oral microemulsion formulation containing Centaurea lycopifolia extraction

Centaurea species commonly found in Anatolia are popularly known used as antidiarrheal, antirheumatic, anti-inflammatory, antibacterial and etc. Centaurea lycopifolia (CL) species are used in Kahramanmaraş in the form of infusion or decoction to heal wounds and cuts. In this study, analgesic and anti-inflammatory effects were investigated in mice and rats by making an oral emulsion formulation from the extraction prepared from the above-ground parts of the CL plant. The extract was prepared from the aerial parts of the plant, then oral emulsion formulation was carried out. The antinociceptive effect of the prepared formulation was examined by Hot-Plate (HP) and Tail-Flick (TF) tests, and its anti-inflammatory effect was examined by Randall-Selitto and Plethysmometer tests. According to the results of the study, oral emulsion prepared from CL extract showed more antinociceptive effect than aspirin in HP and TF tests. In inflammation tests, CL extract showed anti-inflammatory activity close to aspirin. Keywords : Centaurea lycopifolia, Analgesic effect, Antiinflammatory effect, Hot-plate, Mouse