Comparison of bone mineral density, tissue transglutaminase and marsh staging in adolescents and children with celiac disease

ABSTRACTCOMPARISON OF BONE MINERAL DENSITY, TISSUE TRANSGLUTAMINASE AND MARSH STAGINGIN ADOLESCENTS AND CHILDREN WITH CELIAC DISEASEImportance of celiac disease has been increased recently owing to wide use of serological screening tests so it is possible to know real prevelance of disease. The aim of this study is detecting of relations between BMD, histopathologic findings and plasma tTG levels in children and adeloscent with celiac disease.A total of 118 biopsy proven celiac patients (61 females and 57 males) were included in the study. Cut-off point for tTG was accepted equal and above 20 U/mL. Mean diagnostic age of cases was 105.1 ± 50.1 month ( 22 ? 207 month) . While the mean height Z score was -2.20 ± 1.55 SD the weight Z score was -1.54 ± 0.85 SD. Failure to thrive was most prominent complaint in our cases as seen in 65 (55%) of 118. First BMD Z score values of cases were -5.2 to 0.7 (mean: -1.54 ± 1.15 ). Histological evaluation of biopsy specimen revealed 10 patients (9%) Marsh 2, 27 patients (23%) Marsh 3a, 50 patients (42%) Marsh 3b and 31 patients (26%) Marsh 3c.There was no statistically significant difference between Marsh score groups first BMD Z score and tTG value (respectively, p=0.190, p=0.379). There was a statistically significant negative correlation between cases? first BMD Z score and their tTG values (r = -0.281, p=0.002). According to this result if cases? tTG level elevated their first BMD Z score was decreased with same ratio.In conclusion comparison of Marsh score with first BMD Z score and tTG value was not different statistically in children and adeloscent with celiac disease.Key Words: Bone mineral density, celiac, Marsh staging