The role of hydrogen sulphid on experimental cerebral vasospasm

Aneurysmal subarachnoid hemorrhage has an incidence of 6-11/100.000. Cerebral vasospasm describes narrowing of cerebral arteries. Symptomatic cerebral vasospasm occurres in approximately 30% of patients after subarachnoid hemorrhage (SAH) due to intracranial aneurysm rupture. Almost half a century, researches performed a wide range of cerebral vasospasm study but it is still not at the desired point for the causes and treatment. Hydrogen Sulfide (H2S), the third gaseous neurotransmitter after nitric oxide and carbon monoxide in the body. CBS is the major enzyme which is responsible for the synthesis of H2S, in the central nervous system, while CSE is more effective in the cardiovascular system. In neurological, cardiovascular, gastrointestinal, genitourinary, and endocrine systems many effects of H2S have been identified. It plays many roles in many physiological and pathological conditions, but its effects on cerebrovascular system are controversial. In this study, in normal rats and rats with cerebral vasospasm, investigating the role of H2S, by detecting the H2S levels in basilar artery and analysing how the H2S donors and inhibitors effect the cerebral vasospasm were aimed. In control, SAH, NaHS, AOAA, PPG, SAH+NaHS, SAH+AOAA and SAH+PPG groups, the basilar artery lumen diameter and wall thickness, CBS and CSE enzyme activity in basilar artery and brain stem were assessed by immunohistochemistry. As a result, the study which examines the role of H2S in cerebral vasospasm after SAH, the therapeutic potential H2S with its vasodilator activity is observed.