Evaluation of insulin resistance in patients with cholethiasis

Gallstone (GS) diseases highly prevalent with a complex and multifactorial pathogenesis that cholesterol gallstones is the most common disease associated with biliary lipid abnormalities. Fasting blood sample and gallstone were collected from 140 patients with gallstone submitted to cholcystoctomy in Azady Teaching Hospital in Kirkuk City from 1st April 2022 to the end of September 2022. They were divided into two study groups: GS patients with control (100 subjects with GS, 40 subjects control). Insulin, Lipid Profile(Cholesterol, Triglyceride, LDL-C, HDL- C, VLDL), Glucose, as well as measurement of HOMA-IR, BMI and stone analysis. The results of this study showed that the cholesterol gallstone was more common type than pigment or mixed stone, females have a greater risk of gallstone disease than males at all ages and the ratio of females to males was 3.1:1. The obesity is associated with gallstone formation showed that, BMI has high significant (p=0.001) difference between patients with gallstonecompared to control in both gender (males and females). Profound effects of lipid profile of serum lipids metabolism and lipoproteins on the gallbladder formation, showed : significant difference in TC, TG, LDL and VLDL for patients with gallstones compared with control. There was a high level of insulin in the serum of patients with gallstone compared with control, the mean level was,(10.2 ± 5.24μIU/mL).