Comparison of regeneration capacity of different mesenchymal stem cell lines after inflammatory damage

The pathogenesis caused by the extracellular matrix immunoinflammation is fully understood, but the regeneration effect is not sampled in many tissues. Immunological damage occurs in tissues exposed to extracellular matrix proteases due to inflammation and increases in cellular mediators. In this case, the swelling redness and temperature increase occur in these damaged tissues, which causes pain and movement restriction. Hence, molecular alteration of stem cells in such pathogenesis and cellular regeneration of these damages are currently discussed in the literature. Migration of the stem cells to the extracellular matrix where the damage is experienced due to migration from the damaged tissue, which results in the acceleration of the destruction of the tissue due to the occlusion of some tissue repair mechanisms. Stem cells require microenvironmental niches to regenerate. In many studies on regeneration mechanisms, the pathways that work in stem cells are well understood. I concentrated on the JUNB, MEPE, MMP13, MMP2 proteins involved in these pathways. The proteins encoded by these genes function in important functions such as stem cell remodeling, asymmetric cleavage, tissue repair. It has been argued that the effect of tissue inflammation on tissues in tissue has lost its role in stem cell migration. The loss of their ability to regenerate the tissue was thought to be due to the degradation of microenvironmental niches and the decrease in their ability to hold