Investigation of thiol disulfide homeostasis and ischemia modified albumin (İMA) levels in feline panleukopenia

In this study, it was aimed to investigate the thiol disulfide balance and ischemia modified albumin (IMA) levels in Feline Panleukopenia. The study was carried out by collecting whole blood and blood serums from 40 cats, 20 in the patient group and 20 in the healthy group, who came to Ankara University Faculty of Veterinary Medicine, Department of Internal Medicine for general examination. Commercially produced and immediately available rapid test kits (Anigen Rapid FPV Ag Test Kit, BioNote, Inc, USA) were used to diagnose feline panleukopenia. In the study, serum native thiol (Nt), total thiol (Tt), disulfide (Dis), % disulfide/total thiol (%Dis/Tt) and % disulfide/native thiol (%Dis/Nt) ratio and IMA value were measured. Twenty cats (50%) included in this study were divided into the Healthy Group (SG), and 20 cats (50%) as the Diseased Group (HG). The ratio of male cats in SG is 40% (8/20), while the ratio of male cats in HG is 45% (9/20). When the variables related to the thiol disulfide balance were examined between the two groups; The difference between the two groups in terms of native thiol (p<0.001), total thiol (p<0.001) and disulfide (p=0.003) variables was found to be statistically significant. In terms of IMA (p=0.062), % disulfide/native thiol (p=0.776), % disulfide/total thiol (p=0.865), % native thiol/total thiol (p=0.866) values no statistically significant difference was observed. In conclusion, it is thought that oxidative stress parameters change in disease states and these parameters should be evaluated in both diagnosis and treatment.