Personali̇ty characteri̇sti̇cs of pati̇ents wi̇th fi̇bromyalgi̇a, and to compare the effecti̇veness of pregabali̇n and duloxeti̇ne treatments i̇n these groups

Aim: After the separation of the patients with Fibromyalgia syndrome (FMS) according to their personality traits, to investigate the efficacy of duloxetine and pregabalin treatment on these personality traits and to compare these effects with each other. Patients and Method: 103 female patients are taken to the study which are diagnosed with FMS without other disease. Three groups were determined as neurotic, extroverted and neurotic-extroverted with using the Eysenck Personality Questionnaire Short Form. These three groups randomly divided to two groups between themselves, and one of the these groups were treated with 60 mg/day duloxetine and the other group were treated with 300 mg/day pregabalin throughout 12 weeks. Patients pre-treatment and post-treatment pain levels with using Visual Analogue Scale, depression levels with using Beck Depression Scale, quality of life with using SF-36 Quality of Life Scale, and the functional status with using Fibromyalgia Impact Questionnaire were determined. Results: We found that FMS is seen more in people who neurotic personality structure, and pregabalin and duloxetine which are use in FMS treatment improved scores of pain, tender points, quality of life and depression. When the groups of personality are evaluated we determined that recovery is seen in extroverted groups in the SF-36 quality of life scale energy (vitality) sub-parameters and FIQ score, and improvement is seen more in the neurotic group in the Beck Depression Scale. When the drugs used in medical treatment are compared with each other we found that both drugs provided clinical improvement in all parameters except emotional role limitations of SF- 36 quality of life scale and social functioning subgroups, and treatment of pregabalin was more effective in extroverted groups in VAS pain score. Discuss: We determined that FMS is seen more in people who neurotic personality structure, pregabalin and duloxetine are effective on all personality groups, and treatment of FMS patients who have neurotic personality structure is harder than extroverted personality patients in some parameters. We conclude that pregabalin treatment should start initially to extroverted personality patients, and new treatment options should investigate due to lack of improvement in the emotional role limitations and social functioning. Key Words: Fibromyalgia syndrome, personality traits, pregabalin, duloxetin