Relation of RGS4 gene with schizophrenia

Objective and Hypothesis: RGS4 gene is one of schizophrenia candidate genes, which are figured to be related with schizophrenia after various association and linkage studies. The aim of this study is to genotype four of SNPs of RGS4 gene [SNP1(rs10917670), SNP4(rs951436), SNP7(rs951439), SNP18(rs2661319)] and to investigate the association of these determined genotypes with schizophrenia.Methodology: DNA samples, that had been extracted from two cc peripheral blood samples, were amplified via PCR by using specific primers. PCR products were shipped for sequence analysis. Outputs of the analysis were evaluated together with clinical symptoms.Findings: 100 patients and 52 control subjects were studied. As a result of x2 test for genotypes, p values are obtained as 0.12 for SNP1, 0.73 for SNP4, 0.10 for SNP7, and 0.14 for SNP18 (p>0.05). P valeus for alleles were calculated as 0.057 for SNP1, 0.56 for SNP4, 0.06 for SNP7, and 0.066 for SNP18 (p>0.05).Results: In our study, it is indicated that there is no statistically significant association between four SNPs and schizophrenia.Keywords: Schizophrenia, RGS4, SNP, candidate gene, genotype