Development medical textile product and wound dressings for gout disease treatment

In this study, it is planned to develop product/products that can be used in reducing the high uric acid concentration in the blood, which is the cause of gout. This product/products will not only be used in gout but also in diseases caused by high uric acid concentrations in the blood such as acute uric acid nephropathy, nephrolithiasis, and chronic urate nephropathy. The uric acid crystals accumulated in the joints in gout are tried to be eliminated. The reason for the accumulation of uric acid crystals is due to the little or no activity of the uricase enzyme in patients. Since the bioconversion of uric acid cannot be achieved in metabolism, the concentration of uric acid in the blood increases. As the uric acid level, whose solubility is already low, increases in the blood, it accumulates in the form of crystals, especially in areas with poor circulation. Even at the advanced levels of the disease, especially in the joints due to the accumulation of crystals, wounds occur and even the uric acid crystals appear on the wound. As a result of this situation, the patient suffers greatly. As a result of this situation, the patient suffers greatly. Microbial production of nitrilase enzyme, optimization of production and modification of polyacrylonitrile (PAN) fabric under optimum conditions; The microbial production of the uricase enzyme, the optimization and purification of the production, and the immobilization of the purified uricase enzyme to the modified PAN fabric and the optimization of the immobilization and the uricase were also immobilized in different support materials. As a result, the developed product/products will be designed for use in the treatment of gout. Thus, the high concentration of uric acid in the blood will be reduced during treatment. Therefore, if uric acid crystals are present in the patient, they will begin to dissolve in the blood and move away from the tissues in the crystals. Keywords: Gout disease, uricase, nitrilase, polyacrylonitrile fabric, immobilization.