The investigation of the effect of some flavonoids on hekzokinase 2 enzyme activity

Cancer is located in the first location among the World health problems, and it became the topic for lots of different researches. In performed studies, the biochemical changes in the glycolysis metabolism occurred inside the cancer cell can be guidance to the cancer diagnosis and therapy. In the present studies show that cancer cells consume glucose 10-15 times more than the typical cell to provide their energy demand. The pathway of this energy production is known as glycolysis. With the inhibition of the glycolysis pathway, we can both disrupt the metabolic balance of cancer cell and limits the energy sources of the cancer cell. For these purposes, in the present thesis studies, the inhibition of HK-II enzyme, which is the first-rate restricting step of the metabolic pathway of the glycolysis have been studied by using some phenolic compounds.