Synthesis and characterization of 1,3-diaryl-2-propene-1-onw derivatives bearing heterocyclic units

Chalcones are named as 1,3-diphenyl-2-propen-1-one, unsaturated ketone compounds which belong to the flavonoid family. Also, chalcones are important building blocks used to synthesis of various heterocyclic compounds such as pyrimidines, pyrazolines, oxazolines, benzothiapines, etc. Chalcones and their heterocyclic derivatives have been known to possess many pharmacological activity such as anticancer, antiinflammatory, antimicrobial, antioxidant, antimalarial, antileishmanial, antiulcer, antiviral, antiprotozoal and anti-HIV. In the present work, the new chalcones with potential biological activity were synthesized. Twenty novel 3-[(4-substituted-1-yl)phenyl]-1-aryl/heteroaryl-2-propen-1-one derivatives (1a-d, 2a-d, 3a-d, 4a-d and 5a-d) were synthesized starting from 4-substituted- benzaldehydes and aromatic/heteroaromatic methyl ketones by Claisen-Schmidt condensation reaction. All reactions were completed after they monitored by Thin Layer Chromatography (TLC). The crude products were extracted and recrystallized with appropriate solvents. The chemical structures of chalcone derivatives were eludicated by UV-Vis FT IR, 1H NMR, 13C NMR and MS spectral data and elemental analyses (CHNS).