The inhibition effects investigation of metal complexes of schiff bases of some sulfa drugs on alpha-glucosidase activity

Regulations of carbohydrate absorption via α-glucosidase enzymes competitive inhibition improve glycaemic control in patients with T2DM; thus, attempts to design new 𝛼-glucosidase inhibitors have become a point of interest. However, most investigations focus mainly on sugar mimics, which are challenging to tackle synthetically. In this in vitro study, nine derivatives of Sulfa-Schiff bases compounds were tested as α-glucosidase inhibitors. Spectroscopic techniques examined each analog activity. All of the ligand complexes were found to be active when screened for alpha-glucosidase inhibition and exhibited IC50 values ranging from 0.429 to 8.976 µM. Compounds (1, 4, 5, 7, 8, and 9) demonstrated impressive inhibitory potential against the α-glucosidase enzyme. All derivatives underwent a molecular docking procedure to clarify their ligand-receptor binding interactions.