The investigation of the inhibition effects of metal complexes of schiff bases of some sulfa drugs on 6-phosphogluconate dehydrogenase activity

In particular, this study is interested in the 6PGD enzyme. In the absence of 6PGD, cancer cells die and cannot propagate. There is no correlation between a 6PGD deficiency of less than 1% and either the development or progression of cancer. Cell development is negatively affected by the inhibition of 6PGD, which controls cell growth and division. Cancer and the glucose metabolic pathway. Cancer cells need 6PGD for the synthesis of NADPH and DNA. When SIRT2 is activated, it blocks the production of NADPH and slows down DNA synthesis. Oncogenic alterations in Ras, Src, and PI3K/AKT all lead to increased 6PGD activity in cancer cells. The 6PGD gene has been linked to glioma, lung, and ovarian cancer (ROS). The 6PGD gene affects the effectiveness of therapy. BCG expression is associated with a poor outcome in bladder cancer. Treatment response and survival time for gliomas may be predicted using 6PGD. We used spectrophotometric techniques to examine the impact of several Schiff bases and their complexes on 6PGD activity in vitro. The program Molegro Virtual Docker was also used to assess probable attachment patterns.