Association between the interleukin-1 beta (IL 1β) gene polymorphism and ovarian cancer

Ovarian cancer (OC) is a leading cause of mortality and a common type of cancer among women. Due to the difficulty of diagnosis in early stages, the prognosis of ovarian cancer is poor. Many non-modifiable and modifiable risk factors could increase the susceptibility to developing this disease. One of the non-modifiable risk factors that has a great impact on developing OC is the genetic factor. Interleukin-1β (IL-1β), is a cytokine activator that plays a role in different physiological and pathological events, upregulation of IL-1β have been shown in solid tumors, including melanoma, colon, lung, and breast, and high levels of urinary and serum IL-1β have been detected in epithelial ovarian cancer . This thesis study, it is aimed at examining the relationship of the disease with IL-1β (rs16944) polymorphism which is thought to affect the risk of ovarian cancer. We had two groups, patient group with ovarian cancer (n = 41) and control group (n = 41). Genotyping of both groups was determined by Real-Time PCR, and the statistical analysis of the data was performed by SPSS program. According to our results, AA genotype (homozygote wild type) was found in 8 (19.5%), GA genotype (heterozygote type) in 15 (36.6%), GG genotype (homozygote variant type) in 18 (43.9%) in the control group statistically. In the patient group, genotype distributions were determined 4 (9.8%), 16 (39.0%) and 21 (51.2%) respectively. There was no significant relationship in comparison with genotypes between patient and control groups (p=0.450). This study could provide a novel approach for the clinical treatment of ovarian cancer. Key words: Polymorphism, Genotyping, Interleukin-1β (IL-1β), Epithelial Ovarian Cancer, Ovarian Cancer.