The serum paraoxonase and arylesterase activities in patients with cancer

2. ABSTRACTThe serum paraoxonase and arylesterase activities in patients with cancerObjectives: The aim of our study was to determine whether serum paraoxonase(PON1) and arylesterase (ARE) levels and phenotypes distribution is altered newdiagnosis in patients with lung cancer (LC) and to compare the values with those ofhealthy controls.Material and Methods: The study was optained prospective which consist ofthe LC group who has taken new diagnosis and healthy control group who has formedfrom the same age- and sex-matched. Serum PON1 and ARE activities and lipidparameters were measured in 39 subjects in both groups. The PON1 phenotypes aredefined according to the ratio of serum PON1/ARE activity. In statistical evaluation ofdata were performed Mann Whitney-U test, Student t test and Pearson?s correlationanalysis. P value <0.05 was accepted as significant.Results: The PON1 (p<0,001) and ARE (p=0,018) activities was found to belower in the patients with LC compared to controls. PON1 enzyme activity wasdetermined as three different phenotypes in both groups. The low activity PON1phenotype AA in the LC group was more than the control group. The high activityPON1 phenotype BB was high in the control group. Serum PON1 levels in the lowactivity phenotype AA individuals, intermediate activity phenotype AB individualsand high activity phenotype BB individuals in the LC group were lower than thesimilar phenotype individuals in the control group. The ratio of PON1/high densitylipoprotein (HDL) was statistically significant decreased in the LC group than thecontrol group (p=0,009). As the Pearson?s correlation analysis, there was a positivecorrelation between serum HDL level and serum PON1 level both control group(r=0,415, p=0,009) and LC group (r=0,496, p=0,001). The evaluation of lipidparameters the level of total cholesterol was significantly lower (p=0,014) in the LCgroup compared to the controls whereas other lipid parameters were not lowerstatistically.Conclusion: The patients with LC were determined to be lower serum PON1level and the ratio of PON1/HDL.Keywords: Lung cancer, paraoxonase, phenotype, antioxidant.2