The research of preoperative and postoperative presepsin levels on the effect of remote ischemic preconditioning before cardiopulmonary bypass on the systemic inflammatory response

Introduction: In our study, we investigated the effect of RIPC on the inflammatory response due to CPB by looking at preoperative and postoperative 1st hour and postoperative 24th hour presepsin levels in the study and control groups. Materials and Methods: Eighty-one patients scheduled for CABG surgery with CPB were included in the study. Patients were randomized and RIPC was applied to 40 patients before anesthesia. The remaining 41 patients were determined as the control group. Data were obtained prospectively. The causal relationships between RIPC and factors such as presepsin, CRP, leukocyte levels, cross-clamp duration, cardiopulmonary bypass duration, intensive care and hospital stay, and demographic characteristics of the patients were investigated. Results: There was no significant difference between the groups in postoperative leukocyte and CRP values (p=0.52, p=0.13, respectively). When the preoperative and postoperative 1st hour presepsin values of the patients were compared, no significant difference was found in the control group (p=0.17), but a significant difference was found in the study group (p<0.05). When the presepsin values were compared between the groups, a significant difference was found only in the postoperative 1st hour value (p<0.05). There was no significant difference between the two groups according to the operative parameters (X-Clamp p=0.11, CPB p=0.19). Conclusion: It was observed that RIPC application increased the presepsin levels in the postoperative 1st hour significantly compared to the control group. (p<0.05)