Determination of antifungal aktivity of tick EGG-WAX

The prevalence of fungal infections, which are widespread throughout the world, have increased markedly in recent years. Resistance associated with widespread and irregular use of antifungals which are relatively limited number, is seen as one of the main causes of the problem.It has been reported that the condition of fungal infection makes it necessary to search for new and effective drugs, and this requirement is predicted to increase over time. At this point, it was reported that plant or animal natural substances are the most important sources in the search for new drug alternatives. Studies on ticks in which many bioactive molecules with antimicrobial, anticarcinogenic and other properties have been isolated demonstrate that this arthropod group can be exploited for many purposes. The antibacterial, antimycotic and antiviral activity of the tick egg wax has been examined and some striking results have been obtained. On the other hand, the number of studies and ticks used in this study area is limited; however, there are hundreds of tick species and it is well known that the antimicrobial efficacy of the wax is closely related to the species of ticks. In this thesis study, we investigated the in vitro antimycotic effects of the egg wax of Hyalomma marginatum, Rhipicephalus bursa and Dermacentor marginatus, which have not been previously studied in the world, on Candida albicans ATCC10231, Candida parapsilosis ATCC 22019 and Candida tropicalis ATCC 750, and it was found that the wax of R. bursa showed an inhibitory effect on C. tropicalis ATCC 750 at a certain concentration and no effect was observed in other experiments. As a result; the effect obtained from the related species associated with its biological and ecological characteristics, and it has been concluded that significant results can be obtained in the name of a new generation antifungal discovery from studies standardized in more detail and more effectively with the tick species sharing such and similar biological and ecological characteristics especially with this species. Keywords:Candida, natural antifungal, tick egg wax, Rhipicephalus bursa.