The effect of catalytic asymetric transfer hydrogenation of quinazolinone and quinazoli̇ne as chiral catalyst in the presence of ruthenium

Asymmetric transfer hydrogenation (ATH) reaction draws great attention in terms of synthetic chemistry due to the fact that it is a simple and selective reaction and its industrial use and academic applications have been increasing. Besides, its use in significant steps of many natural products and pharmaceutically important products and its efficiency in terms of yield and enantiomeric excess provide opportunity for studies in this field to grow rapidly. In this respect, Ruthenium (II) complexes which are optically pure and have NN type organic environment have been planned to be prepared. In this thesis, new quinazoline and quinazolinone based ligands will be synthesized starting from amino acids which are natural and commercially available. Although, known quinazoline and quinazolinone ligands used throughout in this thesis, new quinazoline and quinazolinone ligands are also being synthesised and applied in ATH reaction of ketones with Ruthenium in situ. A series of ketones ATH reaction results showed that up to 77% enantiomeric excess of alcohols obtained with high conversion. For the structural characterization of ligands and complexes were analyzed using NMR, IR, and polarimeter. The conversion and enantiomeric excess of the products were monitored by GC attached with chiral columns.