Age-related comparison of serum symmetrical dimethylarginine levels and urea, creatinine levels in hair goats

SDMA is an important marker for determining renal function in both humans and animal models. It has been shown that cardiovascular risk factors additional to renal dysfunction may affect SDMA plasma levels. Hair goats, which are well adapted to different climatic conditions and land types, are the most bred breed in goat breeding in Turkey with a rate of 96%. In this thesis study, it was aimed to investigate the age-related changes in blood serum Symmetric dimethylarginine (SDMA), Urea and Creatinine levels in Hair goats. 40 female Hair goats, housed under the same care and feeding conditions, were used in the study. The study groups were grouped as 0-12 months (Group 1), 1-2 years (Group 2), 2-3 years (Group 3), and 3-4 years (Group 4), with 10 goats in each group. Symmetric Dimethyl Arginine analysis in blood serum samples was performed in accordance with the commercial kit (SDMA) ELISA Kit protocol. Serum urea and creatinine levels were measured on an autoanalyzer. SDMA levels in the blood serum of female goats in groups 1, 2, 3 and 4 were 2,43±0,24, 3.21±0.44, 3.74±0.32 and 4.46±0.59 (p =0.013); Urea levels (mg/dL) were 20±1.87, 24.5±1.43, 24.4±1.82 and 19.1±1.75 (p=0.058); Creatinine levels (mg/dL) were 0.35±0.027, 0.32±0.020, 0.34±0.022, 0.36±0.022 (p=0.648) respectively. While the SDMA levels (ng/mL) obtained in groups 3 and 4 were found to be statistically significantly higher than the values obtained in groups 1 and 2 (p<0.05), no significant difference was found between urea and creatinine values. The findings contribute to the literature knowledge on both the evaluation of SDMA levels and its comparation together with urea and creatinine levels in female goats of different ages.