Detection of prothrombin G20210A mutation at coronary arterial disease

All over the world the coronar artery disease (CAD) is the most important mortality and morbidity factor. The development of CAD is multifactorial and it is known that numbers of hereditary and acquired risk factors are involved this process with different mechanisms. Prothrombin plays a central role in blood coagulation. Normally prothrombin cleaved by Xa-Va complex to form thrombin.Thrombin is reguired in order to convert fibrinojen into fibrin, which is the primary goal of coagulation. The mutation in the 3' untranslated region of prothrombin gene (a G to A substitution at nucleotide position 20210), has been found to lead to significantly associated with elevated levels of prothrombin activity and prothrombin plasma concentration and this leads to an increased amount of thrombin. From the cause of this effect the mutation is associated with an increased risk for arterial and venous trombosis. The prothrombin gene mutation is seen more commonly in the caucasion population. About %l-2 of the general population is heterozygous for the prothrombin gene mutation (PGM). PGM is relatively uncommon in native populations of India, Korea, Africa and North America. In contrast; in Spain rates of %6 have been reported. In our study three hetcrozygous,out of thirty patients with CAD of which were found to have prothrombin G20210A mutation (%10). And in our control group there was a homozigous woman out of thirty healty person (%3). There wasn't a significant difference between patient and control groups. Key Words: coronary artery disease, thrombosis, Myocardial infarction, prothrombin G20210A