Evaluation of the clinical features of the underlying potential etiology of cardiac amyloidosis in patients with a diagnosis of HEART failure with preserved ejection fraction

Heart Failure (HF); It is a condition in which the heart cannot pump enough blood to meet the metabolic and oxygen requirements of the tissues, or it can pump with high filling pressures. Echocardiographically, patients with an ejection fraction (EF) of 50% or more are called heart failure with preserved ejection fraction (HFF). amyloidosis; A total of 213 patients diagnosed with CPHF were included. Of 213 patients with suspected cardiac amyloidosis in the clinic, 99m Technetium - pyrophosphate (99mTc - PYP) cardiac scintigraphy could not be performed because 9 of 46 died during the follow-up and 37 did not come to our follow-ups, so 167 patients who had cardiac scintigraphy were included in the study. 99m Technetium - pyrophosphate (99mTc - PYP) cardiac scintigraphy was performed on 167 patients. A total of 5 (3%) people from the patient group who had hypertension before and became normotensive or hypotensive later on, and all of them were found to be distributed in the positive patient group (16.1%), which was found to be significantly higher in the positive group than in the negative group (p=0.0001). The number of patients with inter-atrial septum thickening, which is one of the other ECHO parameters, was 6 (3.6%) and all patients were seen in the positive patient group (19.4%), and a significant difference was observed compared to the negative group (p=0.0001). It has been shown that 89% of patients with CPHF have at least one of the RFs, and as the number of RF increases, the likelihood of wtATTR is higher in patients. Our study showed that there were approximately 2 RFs suggestive of KA in the entire patient group diagnosed with CPHF, and approximately 1.4 times more RF was detected in patients with CPHF who were diagnosed with ATTR-CA compared to those without. Key Words: HFpEF, Cardiac amyloidosis, Red flag (RF)