Comparison of neostigmine and sugammadex for postoperative nausea and vomiting

ABSTRACT Comparison of Neostigmine and Sugammadex for Postoperative Nausea and Vomiting Purpose: The aim of this study is to compare the effects of neostigmine and sugammadex on the postoperative nausea and vomiting in patients undergoing laparoscopic cholecystectomy sugery. Materials and Methods: This study is accomplished after obtaining informed consent forms from patients and with the approvals of the Ethics Committee and the Anesthesiology and Reanimation Department of the Cukurova University Medical Faculty. 60 patients having an ASA status between 1 to 3 and with a predicted operation time not exceeding 150 minutes were included to the study. Patients randomized with simple indiscriminate methodology were divided into two groups. The firstgroup received neostigmin(Group I), the second group received sugammadeks (Group II) respectively. On arrival in the operating room, routine monitors were applied to the unpremedicated patients for recording HR, non invasive systolic blood pressures (SBP), diastolic blood pressures (DBP), peripheral oxygen saturation (SpO2). For anesthesia induction, all patients were applied thiopental (5-7 mg/kg) and rocuronium (0.5 mg/kg) intravenously and endotracheal entubation was provided. After tracheal intubation, the lungs were ventilated with an N2O/oxygen mixture (FiO2 0.5) and anesthesia was maintained with desflurane. All patients applied tramadol(1,5 mg/kg) for postoperative analgesia. After completion of the surgery, cessation of desflurane and N2O while the last skin sutures were closured and neuromuscular blockade was reversed with atropine and neostigmine or sugammadeks. Extubation time and recover time, postoperative hemodynamic variables and the other advers effects were recorded. Results: Demographic variables were similar in groups. Extübation and recovery times were shorter in group sugammadex than in group neostigmine. Postoperative nausea an vomiting was lower in sugammadex group than neostigmine group at first thirty minutes, but this diffference was not istatistically significant. Conclusion: It is concluded that when neostigmine or sugammadex were applied for decurarization after general anesthesia with desflurane there is no superiority between sugammadeks or neostigmine for postoperative nausea and vomiting Key Words: Tiyopental ,roküronyum,desflurane, neostigmine, sugammadex