Protective effect of thyme leaf on monosodium glutamat-induced metabolic changes

PROTECTIVE EFFECT OF THYME LEAF ON MONOSODIUM GLUTAMAT-INDUCED METABOLIC CHANGES BOZKOYUN DUSAK, Zeynep M.Sc. Thesis, Chemistry Departmant I. Supervisor: Assoc. Dr. Nurhayat ATASOY II. Supervisor: Assist. Prof. Dr.Ahmet Ufuk KÖMÜROĞLU August 2019, 47 Pages Monosodium glutamate is widely used as a food additive and there is increasing concern that excitoxins such as MSG play an important role in the development of metabolic disorders. Therefore, MSG studies are increasing day by day. In this study, the protective effect of thyme plant on the metabolic syndrome caused by MSG was investigated. Thirty two wistar albibo rats were divided into four groups (in each group 8 wistar albibo) as control group, thyme group (250 mg / kg), MSG group (2g / kg) and MSG + oregano group. At the end of the 28-day trial, the rats were sacrificed and their blood samples were taken. Serum was separated by centrifugation. Serum levels of AST, ALT, LDH, AKP, glucose, insulin, urea, cretainine, total protein, albumin were measured by using commercial kits in Van YYU Medical Faculty Biochemistry Laboratory. Serum glucose levels were significantly increased in the MSG group compared to the control group. Serum glucose levels in MSG + thyme group decreased significantly than MSG group. There was a slight increase in serum AST and ALT levels in MSG group. As a result, it was concluded that MSG application may have impaired carbohydrate metabolism by increasing serum glucose levels significantly. It was observed in this study that thyme plant may cause this effect to decrease. Key Words: Glucose, Insülin, Monosodium glutamate, Rat.