Analysis of cerebrospinal fluid in multiple sclerosis and other neurologic diseases

Cerebrospinal fluid analysis is a valuable diagnostic tool for the evaluation of inflammatory, infectious, or non-infectious conditions of the brain, spinal cord, and meninges. Oligoclonal band positivity and intrathecal immunoglobulin G synthesis are the most important findings in the diagnosis of Multiple sclerosis. In neurological, infectious or inflammatory diseases of the central nervous system, quantitative and qualitative abnormal immunoglobulin G findings can be detected in the cerebrospinal fluid. In this study, we aimed to evaluate laboratory oligoclonal band patterns together with relevant immunoglobulin G results, Reibergram analysis and cerebrospinal fluid indices, compare these results with data obtained through clinical diagnosis, and show the effect of the analyzes on the differential diagnosis of diseases. For this purpose, 2273 patients who applied to Hacettepe University Faculty of Medicine Neurology Clinic and met the inclusion criteria were included in the study. Key words: Multiple sclerosis, oligoclonal band, immunoglobulin G, cerebrospinal fluid.