Breath analysis at the attack status of MS patients

For the diagnosis of attack status in patients with multiple sclerosis contrast-enhanced MRI is generally used method. At emergency conditions, MRI may not be reachable. Diagnosis of the attack state of patients with multiple sclerosis is important because during the attack condition, the nervous system is damaged. The method of diagnosis of diseases by breath analysis is non-invasive, risk-free, does not require professionals, ve it enhances life quality of the patients. But There's a lot of ares for researchs. One of the biggest shortcomings in a breath analysis right now is that standards have not been improved. After the determination of tne breath analysis standarts, breath analysis can be used at the hospitals routinely. to diagnose the attack status malondealdehyde amounts of the patients has been investigated. At the literature, during attack status, lipid peroxidation increases. Malondealdehyde can be used as biomarker of lipid peroxidation. The amount of malondealdehyde in the breath of patients ve control group was analyzed by high performance liquid chromatography (HPLC). MDA values were found significantly different in MS patients during attack ve after attacks (p = 0.013). The mean value of MDA values obtained from the patients during the attack was 8.70 ± 2.31 nM ve after the attack this value has been decreased to 6.71 ± 0.82 nM. MDA values were significantly different between patient ve control groups. Both during attack (p = 0.002) ve post-attack (p = 0.038) MDA levels were significantly higher in MS patients.