Synthesis of n-substituted benzimidazole derivatives

In this study, 1H-Benzimidazole was used as starting compound. The synthesis of Ethly-2-(1H-benzimidazole-1-yl) acetate was carried out from the reaction of 1H-benzimida zole with ethyl bromoacetate. 2-(1H-benzimidazole-1-yl)acetohydrazide was obtained by the reaction ethly-2-(1H-benzimidazole-1-yl) acetate with hydrazine hydrate. The synthesis of thiosemicarbazide derivatives of this compound were performed from the reaction substituted isothiocyanates with 2-(1H-benzimidazole-1-yl)acetohydrazide and then, norbornyl substitu ted oxadiazole and triazole derivatives were prepared. Benzimidazole substituted 1,3,4-oxadiazole-2-amine was synthesised from the reaction of CNBr in basic medium. Schiff bases derivatives of this compound were prepared by using ß- hydroxynaftaldehyde and salisil aldehyde. Mannich, N-alkly and N-acyl derivatives of the 1H-Benzimidazole were also synthesized by using different reactive. The structure of synthesized compounds was characterized by using spectroscopic methods such as IR, 1H-NMR and 13C-NMR.Keywords: Benzimidazole, oxadiazole, thiosemicarbazide derivatives