Retrospective investigation of medical and surgical complications of patients with renal transplant diagnosis of autosomal dominant polycystic kidney disease

Autosomal dominant polycystic kidney disease (ADPKD) is a systemic disease associated with cyst formation in the kidneys and other organs and accompanied by other system pathologies. It is often seen that end-stage renal disease (ESRD) develops after the fifth-sixth decade. In this study, we aimed to investigate the follow-up of the patients following renal transplantation in ADPKD and to compare the medical and surgical complications with other reasons for renal transplantation retrospectively. The demographic characteristics, clinical and laboratory findings of the 126 patients (58 patients diagnosed with ADPKD and 68 patients who underwent renal transplantation due to other kidney diseases) were retrospectively evaluated on the hospital electronic file system at Uludag University Medical Faculty Hospital. Postoperative complications, medical treatments, patient and graft survival rates were evaluated statistically. Medical and surgical complications were compared between groups. Urinary tract infection, osteoporosis and cardiovascular system disease were significantly higher in ADPKD patients after transplantation (p <0,05). When the age of transplantation of the patients was examined, it was found that transplantation was performed in the ADPKD group at a later age (p <0,01). When the other complications were evaluated, no difference was found between the two groups (p>0,05). When the graft functions and laboratory creatinine levels were evaluated at the last visit, graft functions were found to be better in the ADPKD group (p<0,05). Patients who develop ESRD due to ADPKD and undergo renal transplantation are at increased risk for various complications, especially urinary tract infection and cardiovascular system disease in the post-transplant follow-up. These patients who are followed up under immunosuppressive treatment after transplantation should be followed up with close clinical follow-up and appropriate treatments if necessary. Key words: ADPKD, kidney transplantation, medical complications.