Investigation of caffeic acid phenethly ester effect on inflammation and oxidative stress in paracetamol induced hepatotoxicity

Paracetamol is a cheap, pain-relieving, fever-reducing medicine that can be easily found. Paracetamol is metabolized in the liver. At high doses, paracetamol causes liver damage hich is called hepatotoxicity. Caffeic Acid Phenyl Ester (CAPE) has antimicrobial, anti-inflammatory and antioxidant properties. Due to its long aromatic and aliphatic carbon structure, it passes easily through the cell wall and reaches the region where it will act more easily. The aim of this study is to understand the CAPE protective effect to hepatoxisitiy oxidative stress and inflamation during the application of paracetamol. In tis study 36 wistar rat was used. Divided into six groups randomly. Control: given only forage. Paracetamol: 2 g/kg döşe of paracetamol. Paracetamol +CAPE: 2 g/kg döşe of paracetamol + 10ug/kg CAPE. Paracematol + NAC: Paracetamol 2 g/kg + NAC (140 mg/kg): 140 mg/kg N-asetil Sistein applied after one hour 2 g/kg dose of 2 mL paracetamol. CAPE:10 microgram/kg CAPE and ethanol group. The data is analyzed statistically SPSS-18 ANOVA standard variaton. (p<0.05) is accepted meaningful. According to the results obtained, it is seen that hepatoxisity induced paracetamol model has more oxidative stress statistically than the control group (p<0.05). The groups which were given CAPE and paracetamol group when compared, CAPE has protective effect to the occuring inflamation