Comparıson of serum CA 125 and HE 4 levels ın patıents wıth pelvıc mass.

Ovarian cancer is the most common cause of the gynecologic cancer death. The prognosis of early stage ovarian cancer is favorable. On the other hand five year survival of advanced stage ovarian cancer is extremely low. CA 125 is commonly used as a tumour marker for patients suspicious of ovarian cancer. High CA 125 levels can be found in lots of benign and malign conditions like endometriosis. Due to low specifity of CA 125 for ovarian cancer, the convenience in differential diagnosis is restricted. The aim of this study is to compare effectiveness of imaging score, serum CA 125 and HE 4 levels in differential diagnosis of pelvic mass. This study include 85 patients who were diagnosed with pelvic mass and operated in our institution. Preoperative serum CA 125 and HE 4 levels, imaging scores and pathology results were evaluated prospectively for all patients. In conclusion, serum HE 4 levels found more sensitive and specific than serum CA 125 levels and imaging score in differential diagnosis of ovarian cancer. It was shown that Serum HE 4 levels rarely increases in endometriomas in contrast with CA 125.