Synthesis of pyrido[3,4-b]carbazole and pyrido[4,3-c]carbazole ring systems

The fusion of the carbazole nucleus at the a, b, and c positions with the pyridine ring at the 2,3- and 3,4-positions results in 12 isomeric pyridocarbazoles, six belonging to the quinoline and six to the isoquinoline series. In this study, 1-methyl-10H-pyrido[3,4-b]carbazole, 1-phenyl-10H-pyrido[3,4-b]carbazole, 1-methyl-7H-pyrido[4,3-c]carbazole and 1-phenyl-7H-pyrido[4,3-c]carbazole, which is a pyridocarbazole derivative, was synthesized via D type synthesis plan. So, for commercially selling 4-oxo cyclohexane carboxylate which was synthesized earlier was used as a starting compound. The pyridocarbazole derivative was synthesized by consecutive synthesis steps to form the forth cycle of this compound. N-[2-(9H-carbazole-3-il)etil]acetamide and N-[2-(9H-carbazole-3-il)etil]benzamide was also synthesized as a midproduct to synthesize new derivatives and its structure was exposed. Synthesized compounds were purified by using chromatographic methods and their structures were identified by using FT-IR and 1H-NMR. Keywords: Pyridrocarbazole, quinoline, isoquinoline