Evaluation of methylentetrahydrofolatreductase, prothrombin g20210a, factor v leiden gene mutation in intrauterin growth retardation and premature in newborn

OBJECTVE: We aimed to evaluate the gene mutation of Methylenetetrahydrofolatereductase (MTHFR), Prothrombin gene 20210A (PG20210A), Factor V Leiden (FVL) in IUGR and premature newborns. MATERIAL and METHODS: 96 newborns were included in this study. In those newborns, we evaluated the association between the risk factors for the thrombosis and MTHFR, PG20210A and FVL gene mutation frequencies. Maternal hypertension, family history of thrombosis and smoking history of the parents were questioned as risk factors for the thrombosis. While premature and IUGR newborns were evaluated as study group, term and AGA groups were evaluated as control group. MTHFR, PG20210A and FVL gene mutation frequencies were analyzed in all groups. IUGR newborns were determined as symetric and asymetric according to ponderal index. The mutation frequencies of MTHFR, PG20210A, FVL were searched in both symetric and asymetric IUGR newborns. RESULTS: When we evaluated the groups according to the risk factors for the thrombosis; in 42 (43.9 %) newborns parents were not smoking and in 54 newborns (56.3 %) the fathers were smoking. No maternal smoking history was present for the cases. The cases who had APGAR scores below 7 in the first minute were not included in the study group. Maternal hypertension was present in 24 (25 %) of the cases no maternal hypertension was present in 72 (75 %) of the cases. Familial thrombosis history was present in the 5 cases (5.2 %). Statistically significant difference was detected between the presence maternal hypertension and presence of the mutation. No statistically significant difference was determined between the history of thrombosis in the family of newborns, parental smoking and the presence of mutations. Statistically significant difference was detected in the premature newborn group compared to the term group in the point of gene mutation frequencies. No statistically significant difference was determined between the IUGR newborn and AGA group in the point of gene mutation frequency. No statistically significant difference was both the symetric IUGR and asymetric IUGR groups for the gene mutation frequencies. CONCLUSION: The presence of maternal hypertension was associated with the increased gene mutation frequencies of MTHFR, PG20210A and FVL. Maternal passive smoking and the history of thrombosis in the family were not found to be associated with the increased MTHFR, PG20210A and FVL gene mutation frequencies. There was an association between the presence of premature newborns and increased MTHFR, PG 20210A and FVL gene mutation frequencies. There was no association betweeen the presence of IUGR and increased MTHFR, PG20210A and FVL gene mutation frequencies. There was no association between the increased MTHFR, PG20210A and FVL gene mutation frequencies and the presence symetric and asymetric IUGR newborns.