Assessment of treatment adherence in hemophiliacs onprophylaxis

Assessment of Treatment Adherence in Hemophiliacs on Prophylaxis Aim: Hemophilia is a bleeding disorder caused by a deficiency of procoagulant clotting factors. Prophylactic treatment regimens reduce bleeding episodes and preserve joint health in hemophilia patients. This study aims to evaluate treatment adherence and joint health in hemophilia patients receiving prophylaxis at our center. Methods: The study included 33 male hemophilia patients: 81.8% had hemophilia A, 15.2% had hemophilia B, and 3% had rare factor deficiencies. Patients' hemophilia diaries and medical records were examined. The "Hemophilia Joint Health Score (HJHS 2.1)" was used to assess the knees, elbows, and ankles. A survey assessed patients' and parents' knowledge about treatment, administration processes, and adherence. Results: Of the patients, 48.5% administered treatment at home, and 9.1% performed self-infusion, typically learned at a median age of 17 with a home nurse's help. The median HJHS score was 0 (0-30), with an average of 2.91±6.03. A strong positive correlation was found between HJHS scores and the number of joint bleeds in the past year. Patients with easy access to a hematology specialist had significantly lower HJHS scores. The treatment adherence rate was 72.4%. Conclusion: The treatment adherence rate was 72.4%. The HJHS score is useful for monitoring arthropathy. Easy access to a hematology specialist is linked to better treatment adherence and joint health. Keywords: Hemophilia, HJHS, prophylaxis, treatment adherence