Investigating the relationship between STAMP2 and SIRT1 in prostate cancer development

The six transmembrane protein of prostate 2 (STAMP2) is an androgen- regulated gene whose mRNA expression is increased in prostate cancer (PCa). Ectopic expression of STAMP2 in prostate cancer cells significantly increases cell proliferation and colony formation. Metabolic studies in different cell lines and identified domains in the protein structure, these data established that STAMP2 may play a role in cellular metabolism. To be able to elucidate the function of STAMP2, we aimed to investigate the relationship between SIRT1 protein and cellular effects of this regulation on PCa cell lines under different metabolic conditions. In this study, we showed that STAMP2 and SIRT1 expression states are in an antagonist regulation and this affects the cell phenotype. The regulation allows us to better understand the proliferation and survival mechanisms of PCa cells, which is important to increase the effect of therapeutic treatments. Further, we found that, under different metabolic conditions, regulation of STAMP2 and SIRT1 has affected mitotic activity, oxidative stress response and DNA damage repair signaling pathways proteins and signal pathways proteins. In the analyzes performed, it has been shown that these parameters regulate cell proliferation. Keywords: STAMP2, prostate cancer, SIRT1, AR signaling pathways.