Prostat kanserinde lipid peroksidasyon biyobelirteçleri malondialdehit (MDA) ve 4-hidroksinonenal (4-HNE) serum düzeyi

Prostate cancer (PCa) is a common cancer diagnosis, and it has become one of the most common causes of cancer death in men. The purpose of this study was to determine the relationship of oxidative stress biomarkers, MDA and 4-HNE with prostate cancer, and their potential risk-modifying influence with age and body mass index (BMI). The prostate is a gland in your male reproductive system. Also, it is an exocrine gland. The functional activity of the prostate is to produce seminal fluid. However, it is susceptible to cancer from time to time. Further, the risk of prostate cancer can be due to both modifiable and non-modifiable risk factors. The first ones are a fault of our lifestyle while the last ones are due to growing old, genetics, etc. Eighty-two male subjects aged 40–82 years were included in this study. This subjects are divided into two groups. There were 42 patients of prostate cancer with histopathological confirmation and 40 healthy controls. Blood samples were first taken and tested. Enzyme-linked immunosorbent assay (ELISA) tests were also run on them. This is for conducting a quantitative determination of the levels of 4-HNE and MDA. The serum quantities of MDA and 4-HNE were found to be significantly higher in the prostate cancer group (MDA: 11.11±2.423 ng/ml; 4-HNE: 0.3737±0.08529 ng/ml or 373.7±85.29 pg/ml) as compared to controls (MDA: 8.423±1.597 ng/ml; 4-HNE: 0.2995±0.04394 ng/ml or 299.5±43.94 pg/ml) with p-values <0.0001. Moreover, the patients also had a significantly higher BMI (28.17±3.707 kg/m² vs. 25.42±2.1 kg/m²) and mean age (63.34±9.888 years vs. 57.58±11.09 years). The study highlights how oxidative stress involvement in prostate cancer development can be harmful. A lipid peroxides' breakdown products like MDA and 4-HNE can damage DNA and bring about mutations. Due to old age or overweight state, oxidative damage further gets multiplied. MDA and 4-HNE may be useful as diagnostic or prognostic marker. Moreover, oxidative stress status of the system may be critical for prevention or management of PCa. Further ongoing studies should use methods combined of molecular, genetic environment etc to make troubleshoots targeted.