Effect of platelet rich plasma on intraabdominal adhesions in rats

Despite the development of surgical technologies, intraabdominal adhesions are one of the most important problem for infertility, abdominopelvic pain, and intestinal obstruction. This study was aimed the efficiency of PRP on preventing postoperative intraabdominal adhesions. In this study, 25 male Sprak Dawley breed rats of 4 months old were used. They were divided into 2 groups equally. Five rats were used as donor and obtained PRP. Following general anesthesia and under routine procedures, all groups was traumatized 1 cm2 area on the ileocecal region While group 1 was served as control with no chemical, the group 2 was locally applied PRP. Relaparatomy was made on the 14 days after surgery The results were evaluated macroscopically and histopathologically. Adhesion and fibrosis scores of PRP group were observed to have significantly decreased compared to the control (P<0.005). There was no significant difference in inflamation between the PRP and control groups (P>0.005). In conclusion, it was determined that PRP was more effective on the preventive of intraabdominal adhesions.