Molecular investigation of the effect of salvia cassia silver nitrate nanoparticles on apoptotic and necrotic cell death in lung cancer cells

Lung cancer is the leading cause of cancer-related deaths worldwide, and current treatment methods face major limitations such as high toxicity and the development of resistance. This situation necessitates the development of more effective and environmentally friendly therapeutic strategies. Nanotechnology, particularly through silver nanoparticles, has emerged as a promising field in cancer research due to their diverse biological activities. In this study, silver nanoparticles were synthesized via a green synthesis approach using extracts obtained from Salvia cassia, a plant naturally grown in Turkey, and the synthesized nanoparticles were characterized by various methods. Subsequently, the biological effects of these nanoparticles on lung cancer cells were evaluated. The Findings showed that silver nanoparticles from Salvia cassia induced cell viability and apoptotic, necrotic cell destruction. In conclusion, the Salvia cassia-based green synthesis approach offers a promising strategy not only for ecofriendly nanoparticle production but also for the potential development of anticancer agents in lung cancer research.