The effects of omega 3 fatty acids on nerve healing in A rat model with sciatic nerve damage

Epineural and extraneural scar tissue formation after surgery is one of the most important factors that negatively affect the outcome of peripheral nerve surgery. Scar tissue and adhesions that develop in the postoperative period cause pain that does not pass along the axis of the nerve and functional loss. Many surgical methods, pharmacological agents and chemicals have been used to prevent epineural scar tissue formation, but satisfactory results have not been obtained in clinical applications. Of the study, it was aimed to investigate the effect of omega 3 on epineural scar tissue and adhesion formation after epineurectomy in rat sciatic nerve in a mature rat model. In the study, 16 Sprague-Dawley female rats were used. Rats were divided into two groups. 0.5 cm circumferential epinurectomy was performed on the first group (n:8) sciatic nerve. In the second group 0.5 cm circumferential epinurectomy was performed and 15 mg/ kg omega 3 was administered once a day orogastric gavage for three weeks. Rats were sacrificed at the end of the 3rd week and macroscopic and histopathological examination was performed. As a result, in the study; it was statistically seen that omega 3 positively affected nerve regeneration.