Evaluation of oxidative metabolism in schizoaffective disorders

In our study we aimed to evaluate the oxidative metabolism?s status in schizoaffective disorder. Blood samples were taken from enrolled subjects in appropriate way and total antioxidant status (TAS) and total oxidant status (TOS) were studied in Harran University Medical Faculty Biochemistry Labs and oxidative stress index (OSI) was calculated. Results were compared between groups. However, TAS values were similar between two groups; in patient group, TOS and OSI values were significantly higher than control group. Additionally, an inversely proportional decrease in TOS and OSI values while the number of manic attacks, depressive attacks, and total attacks had increased. The oxidative equilibrium had destabilized in favor of TOS in schizoaffective disorder. Increased oxidative stress might effect the prognosis of the disease negatively.