Investigation on therpeutic efficacy of teofilin in calves with respiratory diseases

ABSTRACT Investigation on Therpeutic Efficacy of Teofilin in Calves with Respiratory Diseases This study was carried out in a total of 50 calf calves in the Uşak province that were found to have developed a clinical respiratory system problem. Twenty-five animals constituted the control group (KG) while 25 animals constituted the experimental group (DG). KG calves were treated under the classical treatment procedure. In addition to the routine clinical treatment procedure for DG animals, intravenous (iv) theophylline (TECAR® 240 mg/10 ml iv ampul) is administered in the form of slow infusion in a physiological saline 2 times daily at a dose of 6 mg/kg for 3 days). Before and after starting work on all of the animals studied 1.2.3. Clinical, haematological and blood biochemical examinations were performed on days. With the application of theophylline, contraction of the muscles seen in some of the DG animals was formed, and no such symptom was observed in the control group animals. It has been observed that theophylline applications cause some significant changes in hematological parameters, especially in the number of RBCs. The most significant increases were obtained in terms of platelet (PLT). The mean levels of enzyme levels of aspartate aminotransferase (AST), alkaline phosphatase (ALP), sorbitol dehydrogenase (SDH), lactate dehydrogenase (LDH), glutamate dehydrogenase (GLDH), creatinine kinase (CK) decreased progressively in both groups on day 3 (p <0.05), which was statistically significant in terms of all time periods in DG animals compared to KG. As a result; it has been determined that theophylline investigated for the first time in the refrigerator can provide significant improvements in the clinical symptoms of the respiratory system and contribute to recovery. Key words: Theophylline, calf, clinical, hematologic, blood biochemistry