Efficacy of placing a thin layer of gelatin sponge during dural closure i̇n preventing meningo-cerebral adhesion

Harput, M.V., Efficacy Of Placing A Thin Layer Of Gelatin Sponge During Dural Closure İn Preventing Meningo-Cerebral Adhesion. Yeditepe University School of Medicine, Thesis in Neurosurgery, İstanbul, 2013. One significant drawback during a cranial reoperation is the presence of meningo-cerebral adhesions. The appearance of these connective tissue bridges between the inner surface of the dura and the pia-arachnoid is directly related to the dural closure in the previous surgery. This study was done to determine the benefit of using a thin-layer gelatin sponge of polypeptides to prevent the development of meningo-cerebral adhesions. From September 2005 through May 2012, 902 craniotomies were done for various lesions by the senior author (U.T.). Beginning with February 2009 we began placing thin gelatin layers underlying the dural flap with the aim of protecting the brain surface during dural closure and isolating the dural healing. To determine the benefits of this technique, the reoperation cases were inspected prospectively and the degree of meningo-cerebral adhesions were compared between group G (Gelatin) and C (Control) in which the dural closure was made with and without subdural application of the gelatin sponge respectively. Student?s t-test and ? 2 tests were used for comparison for means of the variables and normally distributed data. Results were expressed as the mean ± SD. p ? 0.05 was considered as significant. From September 2005 through May 2012, 902 craniotomies were done for various lesions by the senior author (U.T.). Beginning with February 2009 we began placing thin gelatin layers underlying the dural flap with the aim of protecting the brain surface during dural closure and isolating the dural healing. To determine the benefits of this technique, the reoperation cases were inspected prospectively and the degree of meningo-cerebral adhesions were compared between group G (Gelatin) and C (Control) in which the dural closure was made with and without subdural application of the gelatin sponge respectively. Student?s t-test and ? 2 tests were used for comparison for means of the variables and normally distributed data. Results were expressed as the mean ± SD. p ? 0.05 was considered as significant. From September 2005 through May 2012, 902 craniotomies were done for various lesions by the senior author (U.T.). Beginning with February 2009 we began placing thin gelatin layers underlying the dural flap with the aim of protecting the brain surface during dural closure and isolating the dural healing. To determine the benefits of this technique, the reoperation cases were inspected prospectively and the degree of meningo-cerebral adhesions were compared between group G (Gelatin) and C (Control) in which the dural closure was made with and without subdural application of the gelatin sponge respectively. Student?s t-test and ? 2 tests were used for comparison for means of the variables and normally distributed data. Results were expressed as the mean ± SD. p ? 0.05 was considered as significant.