Use and characterization of collagen obtained from chicken and fish skin in 3D scaffolding

Collagen is the most abundant structural protein found in humans and mammals, especially in the extracellular matrix (ESM). Its primary function is to hold the body together. The collagen superfamily of proteins includes more than 20 identified types. Yet type I collagen is the major component in many tissues and can be extracted as a natural biomaterial for various medical and biological purposes. Collagen has numerous advantageous properties, including diverse resources, biocompatibility, sustainability, low immunogenicity, porosity and biodegradability. Therefore, the relative concentrations and orientations of collagens and their physico- chemical properties provide an ideal environment for cell growth both in vivo and in vitro. Type I collagen-based biomaterials can also be modified to improve their function, such as cross-linking to enhance mechanical properties or adding biochemical factors to enhance their biological activity. In the light of this information, the aim of our study is to obtain collagen type I from different animal species and to investigate its biocompatibility.