Synthesis thizole derivatives and complexes

Various thiazoles exhibit pharmacological activity, e.g., antimicrobial,antihistaminic, antiparazitic, antihelminthic, antipyretic, and antiviral. Suchmedicines as Sulfathiazole, Phthalylsulfathiazole, and related compounds are widelyused in medical practice. Thiazole ring is a structural component of naturalcompounds, e.g., Vitamin B1 (thiamine), penicillin, and carboxylase. Thiazolederivatives are widely used as antioxidants for petrochemical products, vulcanizationaccelerators, and photochromic substances.In this study, a series of 2-amino-4-arylthiazoles were synthesized (TH1,TH2, TH3, TH4, TH5).Compounds were prepared by reactions of acetophenon, 2-acetylnaphtalene,4-methyl-acetophenon, 4,-nitro-acetophenon ve 4-hydroxy- acetophenon withthiourea in the presence of iodine. Reactions of 2-amino-4-arylthiazoles with2-hydroxy-benzaldehyde, teraphthaldehyde ve isonitrosoacetophenon afforded thecorresponding Schiff bases ( L1H, L2H, TO). Complex formation of the latter withnickel and cobalt salts (NiCl2 ,CoCl2) was studied.The structures of ligand and complexes were determined by 1H-NMR,13C-NMR and IR spectroscopy techniques.