Investigation of possible aluminum contamination in total parenteral nutrition (Tpn) solutions and tpn components

Inorganic toxicity awareness and research has been increasingly echoed in the scientific world with increasing exposure to heavy metals. Aluminum (Al), which is one of the known, has attracted attention with its inability to understand its biological function in the body and its long-term toxicity. Humans are exposed to the aluminum because of environment, industry, food additives, and cosmetic products such as deodorant daily used tools almost every day. Al can be used for therapeutic purposes in antacids, antidiarrheals and vaccine adjuvants. Al is scientifically accepted as a neurotoxin and it is known to cause bone disease that long-term exposed. Publications associated with Alzeimer's disease and Al, although not enough evidence has been provided, encourages researchers to investigate Al contamination. Al contamination has been known for many years in total parenteral nutritional (TPN) solutions, which are the parenteral solutions that provide basic nutritional intake to individuals who cannot be fully fed orally or enteral. In particular, intensive care patients, premature infants, malnourished and post-operative hospitalized patients are exposed to high levels of Al intravenously, which increases the likelihood of neurological diseases in the long-term exposed. In the light of these data, we aimed to investigate the presence of Al contamination in TPN solutions. Hospitals in Turkey, Al quantification analysis in TPN solution prepared manually and biological fluids of patients such as blood and urine, is not yet practiced. Within the scope of this thesis, it is aimed to investigate possible aluminum contamination in the components used in the preparation of TPN solutions and TPN solutions where the Pharmacy Unit of Hacettepe University's Hospital. Samples were analyzed by spectrofluorometric method and whether the results reached were in compliance with the determined limits. In addition, this study is thought to be the first link of studies to investigate the relationship between Al toxicity and TPN exposure observed in patients receiving long-term TPN.