Investigation of antitumoral activity in mice of spirulina (Arthrospira) platensis which produced in turkey

Spirulina platensis is a food that belongs to the Cyanophyceae class and is rich in vitamins, minerals and proteins. Ehrlich Acid Tumor (EAT) used in our study is an experimental tumor model with transplantation capability specific to mice. In this study, the efficacy and therapeutic properties of S. platensis at different doses (200 mg / kg - 800 mg / kg) were investigated. Our study consists of 7 groups (n = 6) and a total of 42 Balb-C mice were used. Animals in the experimental groups were administered EAT intrapritoneally and S. platensis was administered by gavage. At the end of the experiment, biochemical parameters (TAS, TOS, ALT, AST) were examined from the blood taken from mice by the giotin method. The kidney, stomach, small intestine and large intestine tissues were taken from the animals and the presence of tumor development in the tissues was evaluated pathologically with the help of light microscopy. During the experiment, the experimental animals in all groups were weighed daily and weight changes were recorded. As a result of the study, it was determined that there was a statistically significant difference between TOS values in the 200 mg / kg treatment group (p <0.05). Significant differences in oxidant values were detected in the treatment group of S. platensis produced in Turkey. In the pathological evaluation, it was determined that the spread of the tumor in organs such as the colon and stomach was statistically significantly different (p <0.05). It is thought that our study will help the studies in this area.