Antibacterial and anti-biofilm potency of some medicinal plant extracts against antibiotic-resistant pathogenic bacteria isolated from burns and wounds

100 sample were collected from burns and wounds patients in Baghdad Medical City hospitals. The results of the microbial isolation showed Pseudomonas aeruginosa bacteria with a percentage of (26%), Staphylococcus aureus bacteria with an isolation rate of (25%), and Acinetobacter baumannii bacteria with an isolated percentage of (17%), and Enterococcus faecalis bacteria with an isolation percentage (of 16%). All isolates were subjected to an antibiotic sensitivity test. The results showed 14 multi-drug-resistant isolates, which are (P. aeruginosa, S. aureus, A. baumannii, and E. faecalis) these resistant isolates were subjected to a biofilm production test. All plant extracts of both plants were effective in inhibiting the growth of all bacterial isolates, the minimum inhibitory concentration values in both plants ranged between 400 mg/mL and 12.5 mg/mL. The alcoholic and acetone extracts were more efficient than the aqueous extracts in inhibiting the growth of bacterial isolates in both plants (C. officinalis and H. perforatum). C.officinalis extracts recorded the highest percentage of biofilm inhibition in Acinetobacter baumannii bacteria, where the percentage of inhibition was 81% at MIC of (25 mg/mL) in the alcoholic extract, and (67%) at MIC (12.5 mg/mL) of acetone extract. 2023, 78 pages Keywords: Antibiotics, Bacteria, MIC, Plant extracts