Investigation of the reactions of new dihydroprimidine derivatives with propargyl bromide

In this study, new thioxoprimidine derivatives and new thiazolo-pyrimidine derivatives were synthesised from pyrimidine derivatives, which are widely used in the pharmaceutical industry and medicine in the fight against bacterial infections, cancer, AIDS and various other such diseases. In the first step of our study, HCl catalysed reactions of 2,2-dimethyl-1,3-dioxane-4,6-dione with various aromatic aldehydes and thiourea were carried out for the synthesis of new thioxoprimidine derivatives. In the second stage of our study, the reactions of the new thioxoprimidine derivatives with propargyl bromide under potassium carbonate catalysed conditions were investigated and new thiazolo-pyrimidine compounds were obtained. 1H-NMR, 13C-NMR, LC-MS and IR spectroscopies were used to characterise these compounds.