Preparation of new generation nanocomposites/nano drugs and investigation of anticancerogene-antimicrobial drug potentials

In this thesis, the biogenic platinum nanoparticles (Pt NPs) were synthesized by using black cumin seed (Nigella sativa L.) extract as a reducing agent. The biogenic platinum nanoparticles synthesized by black cumin seed extract was characterized in detail by Fourier Transform Infrared Spectroscopy (FT-IR), Transmission Electron Microscopy (TEM), UV-Vis spectrophotometer, X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS). Moreover, the biogenic Pt NPs was assessed for its cytotoxicity effect on MDA-MB-231 breast and HeLa cervical cancer lines and their antibacterial effect towards selected strains of gram-positive and gram-negative bacteria. The cytotoxicity and bacterial tests showed the effectiveness of biogenic Pt nanoparticles. Dose-dependent toxicity effects were shown in the MDA-MB-231 breast and HeLa cervical cancer lines (IC50: 36.86 μg/mL and 19.83 μg/mL, respectively). These results may contribute to the development of Pt NPs synthesized using black seed extract as a potential antibacterial and anticancer agent in the pharmaceutical industry.